![]() Aronson isolated a Mycobacterium from tubercles observed predominantly in the spleen and liver of diseased fish that had died in the Philadelphia AquariumĪnd named it Mycobacterium marinum ( Aronson 1927). marinum to better understand the determinants of pathogenesis of tuberculosis. The work described herein provides a foundation for using M. That produces disease strikingly similar to M. marinum has maintained a large genome so as to retain the capacity for environmental survival while becoming a broad host range pathogen Primates without retaining an environmental niche. tuberculosis has undergone genome downsizing and extensive lateral gene transfer to become a specialized pathogen of humans and other Comparisons with the more distantly related Mycobacterium avium subspecies paratuberculosis and Mycobacterium smegmatis reveal how an ancestral generalist mycobacterium evolved into M. Orthologs with an average amino acid identity of 85%. tuberculosis pathogenesis, and genome comparisons confirmed the close genetic relationship between these two species, as they share 3000 marinum is used widely as a model organism to study M. Some of the NRPS genes comprise a novel family and seem to have been acquired horizontally. Prominentįeatures are the very large number of genes (57) encoding polyketide synthases (PKSs) and nonribosomal peptide synthases (NRPSs)Īnd the most extensive repertoire yet reported of the mycobacteria-restricted PE and PPE proteins, and related-ESX secretion marinum comprises a 6,636,827-bp circular chromosome with 5424 CDS, 10 prophages, and a 23-kb mercury-resistance plasmid. Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. 9 Global Health Institute, EPFL, Station 15, CH-1015, Lausanne, Switzerland.8 Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.7 Department of Microbiology, University of Washington, Seattle, Washington 98195, USA. ![]() ![]() 6 Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, 75015 Paris, France.5 Department of Microbiology, University of Tennessee, M409 Walters Life Sciences, Knoxville, Tennessee 37996-0845, USA.4 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.3 Department of Infectious Diseases, Austin Hospital, Heidelberg 3084, Australia.2 Victorian Bioinformatics Consortium, Monash University, Clayton 3800, Australia.1 Department of Microbiology, Monash University, Clayton 3800, Australia. ![]()
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